Senior Scientist II - Automated Cell Biology

• Design, plan, lead and deliver internal and client research projects

• Perform in vitro experiments and assays to an exceptional standard

• Maintain mammalian cell cultures across a variety of scientific fields and disease settings (e.g. cancer, neuroscience, cardiovascular)

• Develop and optimise cell based assays utilising the automation platform

• Data analysis, interpretation and presentation (including written reports and presentations) of experiment results

• Thorough documentation of performed work in an electronic lab notebook

• Following standard operating procedures and establish or review new SOPs when required

• Providing feasibility assessments and scoping of projects in advance to aid the sales team

• Provide subject matter expertise in meetings with internal and external stakeholders to drive internal process improvements and set best practice standards 

• Keep up to date with relevant scientific and technical developments

• Work well within a team to optimise processes, mentor others and learn

• Contribute ideas to technology development strategies and a culture of continual improvement

Essential:

• Education to Ph.D level in cell biology or related fields; equivalent experience in scientific R&D

• 2+ years of postdoctoral industrial drug discovery experience

• Experience and expertise in immunology, particularly in a drug discovery context

• Proficiency in multiparameter flow cytometry and/or high content imaging and associated analyses.
  

• Proven ability to disseminate research results e.g. in reports, presentations, posters

• Assay development expertise for target ID/validation and/or drug screening, with a good understanding of assay statistics (e.g. Robust Z’, %CV).

• Experience and knowledge of research processes and activities and requirements to comply with Human Tissue Act

• Good understanding of the drug discovery process

• Experience handling large datasets including data QC and analysis

• Broad-based experience in cell biology, ideally including:

  • Mammalian cell culture and complex cell models (such as 3D cell models, iPSC or other primary cell systems or co-cultures) including development/optimisation of culturing conditions.

  • Implementing, performing and troubleshooting a broad range of cell based assays (for example: flow cytometry, imaging microscopy or plate-based assays (such as NanoBRET, HiBiT, ELISA, Luciferase, HTRF or AlphaLISA).

Desirable, but not essential: 

• Experience in the use, programming and troubleshooting of robotic liquid handlers.

• Experience with T-Cell activation assays or immunogenicity workflows e.g MAPPs assays or TCR sequencing

• Experience using the iQue and/or MacsQuant flow cytometers

• Experience in executing assays using an automated platform including troubleshooting and method validation.

• Experience line managing 1 or more direct reports

Arctoris a leading drug discovery services company advancing drug discovery experimentation. We combine our unique automated laboratory and data science platform, Ulysses™, with a world-class team of seasoned drug hunters to guide and rapidly progress drug discovery programs from target to hit, lead, and candidate.

https://www.arctoris.com/

Our Culture

• Dedicated, passionate and agile team who are constantly innovating and celebrating team successes

• Flexible and collaborative work culture with extensive development and progression opportunities

• Inclusion, diversity and belonging is core to our success.  We embrace everything unique and continue to be proud of our diverse, rich culture.  When you are at your best, we are at our best

Our Benefits

• Highly competitive reward package

• Pension scheme, 4x life insurance, long-term absence insurance and other benefits, including salary sacrifice schemes such as Tusker cars, Nursery cover, gym membership and bike to work

• Generous sick pay scheme and enhanced family-friendly policies

• Personalised health and well-being support

• A minimum of 28 days’ annual leave, together with generous flexible and remote working opportunities to ensure you have a great work/life balance